When used together with indirect oral anticoagulants (coumarin derivatives), testosterone can enhance their effect, and therefore requires frequent monitoring of prothrombin time and, if necessary, reducing the dose of anticoagulants.
Insulin and other hypoglycemic drugs
Androgens can increase glucose tolerance and reduce the patient's need for insulin or other hypoglycemic drugs, therefore, patients with diabetes should periodically monitor glycemia during testosterone therapy, especially at the beginning and at the end of therapy.
Concomitant administration of ACTH or GCS can cause increased peripheral edema, especially in patients with liver disease, heart disease, or a tendency to form edema.
Medicines that induce liver enzymes
Inducers of microsomal liver enzymes, with simultaneous use, can reduce the concentration of testosterone in the blood plasma, which may require a dose adjustment of testosterone.
Medicines that inhibit liver enzymes
Inhibitors of microsomal liver enzymes, when used simultaneously, can increase the concentration of testosterone in the blood plasma, which may also require a dose adjustment of testosterone.
Influence on the results of laboratory tests
Androgens can reduce the concentration of thyroxine-binding globulin, which, in turn, leads to a decrease in the concentration of triiodothyronine (T4). The concentration of free thyroxine (T3) does not change. No clinical manifestations of thyroid dysfunction have been identified.